Blar i forfatter "Holme, Pål Andre"

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    • Anti-PF4/polyanion antibodies in COVID-19 patients are associated with disease severity and pulmonary pathology 

      Ueland, Thor; Sørvoll, Ingvild Hausberg; Mørtberg, Trude Victoria; Dahl, Tuva Børresdatter; Lerum, Tøri Vigeland; Michelsen, Annika Elisabet; Ranheim, Trine; Nezvalova-Henriksen, Katerina; Dyrhol-Riise, Anne Ma; Holme, Pål Andre; Aaløkken, Trond Mogens; Skjønsberg, Ole Henning; Barratt-Due, Andreas; Ahlen, Maria Therese; Aukrust, Pål; Halvorsen, Bente (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-28)
      Thromboembolic events are frequent and associated with poor outcome in severe COVID-19 disease. Anti-PF4/polyanion antibodies are related to heparin-induced thrombocytopenia (HIT) and thrombus formation, but data on these antibodies in unselected COVID-19 populations are scarce. We assessed the presence of anti-PF4/polyanion antibodies in prospectively collected serum from an unselected cohort ...

    • Complement activation is a crucial pathogenic factor in catastrophic antiphospholipid syndrome. 

      Barratt-Due, Andreas; Fløisand, Yngvar; Lang, Hilde Elisabeth; Kvam, Ann Kristin; Holme, Pål Andre; Bergseth, Grete; Tjønnfjord, Geir Erland; Mollnes, Tom Eirik (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-04-22)
      Catastrophic antiphospholipid syndrome is associated with excessive complement activation explaining the clinical efficacy of complement inhibitory treatment.

    • Immune complexes, innate immunity, and NETosis in ChAdOx1 vaccine-induced thrombocytopenia 

      Holm, Sverre; Kared, Hassen; Michelsen, Annika Elisabet; Kong, Xiang Yi; Dahl, Tuva Børresdatter; Schultz, Nina Haagenrud; Nyman, Tuula Anneli; Fladeby, Cathrine; Seljeflot, Ingebjørg; Ueland, Thor; Stensland, Maria; Mjaaland, Siri; Goll, Guro Løvik; Nissen-Meyer, Lise Sofie Haug; Aukrust, Pål; Skagen, Karolina Ryeng; Gregersen, Ida; Skjelland, Mona; Holme, Pål Andre; Munthe, Ludvig Andre; Halvorsen, Bente (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-18)
      Aims - We recently reported five cases of vaccine-induced immune thrombotic thrombocytopenia (VITT) 7–10 days after receiving the first dose of the ChAdOx1 nCoV-19 adenoviral vector vaccine against corona virus disease 2019 (COVID-19). We aimed to investigate the pathogenic immunological responses operating in these patients.<p> <p>Methods and results - We assessed circulating inflammatory markers ...

    • Thrombosis and thrombocytopenia after HPV vaccination 

      Johansen, Silje; Lægreid, Ingvild Jenssen; Ernstsen, Siw Leiknes; Azrakhsh, Nessar Ahmad; Kittang, Astrid Marta Olsnes; Lindås, Roald; Gjertsen, Bjørn Tore; Vetti, Nils; Mørtberg, Trude Victoria; Sørvoll, Ingvild Hausberg; Holme, Pål Andre; Ahlen, Maria Therese; Reikvam, Håkon (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-24)
      Background - Vaccine-induced immune thrombotic thrombocytopenia (VITT) has so far only been reported after adenovirus vector severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines.<p> <p>Objective - We report findings in a 25-year-old woman who presented with thrombocytopenia, venous thrombosis, elevated D-dimer levels, and high levels of platelet-activating antibodies to platelet ...

    • Vaccine associated benign headache and cutaneous hemorrhage after ChAdOx1 nCoV-19 vaccine: A cohort study 

      Schultz, Nina Haagenrud; Søraas, Arne Vasli; Sørvoll, Ingvild Hausberg; Akkøk, Cigdem Ahaein; Vetlesen, Annette; Bhamra, Jagjit Singh; Ahlen, Maria Therese; Holme, Pål Andre; Aamodt, Anne Hege; Skagen, Karolina Ryeng; Skattør, Thor Håkon; Skjelland, Mona; Wiedmann, Markus (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-17)
      Objectives Fatal complications have occurred after vaccination with ChAdOx1 nCoV-19, a vaccine against Covid-19. Vaccine-induced immune thrombotic thrombocytopenia (VITT) with severe outcome is characterized by venous thrombosis, predominantly in cerebral veins, thrombocytopenia and anti-PF4/polyanion antibodies. Prolonged headaches and cutaneous hemorrhages, frequently observed after the ChAdOx1 ...

    • Vaccine Induced Immune Thrombotic Thrombocytopenia Causing a Severe Form of Cerebral Venous Thrombosis With High Fatality Rate: A Case Series 

      Wiedmann, Markus; Skattør, Thor Håkon; Stray-Pedersen, Arne; Romundstad, Luis Georg; Antal, Ellen-Ann; Marthinsen, Pål Bache; Sørvoll, Ingvild Hausberg; Ernstsen, Siw Leiknes; Lund, Christian G.; Holme, Pål Andre; Johansen, Tonje Okkenhaug; Brunborg, Cathrine; Aamodt, Anne Hege; Schultz, Nina Haagenrud; Skagen, Karolina Ryeng; Skjelland, Mona Elisabeth (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-30)
      During a 2-week period, we have encountered five cases presenting with the combination of cerebral venous thrombosis (CVT), intracerebral hemorrhage and thrombocytopenia. A clinical hallmark was the rapid and severe progression of disease in spite of maximum treatment efforts, resulting in fatal outcome in for 4 out of 5 patients. All cases had received ChAdOx1 nCov-19 vaccine 1–2 weeks earlier and ...